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Abstract Functional magnetic resonance imaging faces inherent challenges when applied to deep-brain areas in rodents, e.g. entorhinal cortex, due to the signal loss near the ear cavities induced by susceptibility artifacts and reduced sensitivity induced by the long distance from the surface array coil. Given the pivotal roles of deep brain regions in various diseases, optimized imaging techniques are needed. To mitigate susceptibility-induced signal losses, we introduced baby cream into the middle ear. To enhance the detection sensitivity of deep brain regions, we implemented inductively coupled ear-bars, resulting in approximately a 2-fold increase in sensitivity in entorhinal cortex. Notably, the inductively coupled ear-bar can be seamlessly integrated as an add-on device, without necessitating modifications to the scanner interface. To underscore the versatility of inductively coupled ear-bars, we conducted echo-planner imaging-based task functional magnetic resonance imaging in rats modeling Alzheimer’s disease. As a proof of concept, we also demonstrated resting-state-functional magnetic resonance imaging connectivity maps originating from the left entorhinal cortex—a central hub for memory and navigation networks-to amygdala hippocampal area, Insular Cortex, Prelimbic Systems, Cingulate Cortex, Secondary Visual Cortex, and Motor Cortex. This work demonstrates an optimized procedure for acquiring large-scale networks emanating from a previously challenging seed region by conventional magnetic resonance imaging detectors, thereby facilitating improved observation of functional magnetic resonance imaging outcomes. 

Abstract High-resolution air quality data products have the potential to help quantify inequitable environmental exposures over space and across time by enabling the identification of hotspots, or areas that consistently experience elevated pollution levels relative to their surroundings. However, when different high-resolution data products identify different hotspots, the spatial sparsity of ‘gold-standard’ regulatory observations leaves researchers, regulators, and concerned citizens without a means to differentiate signal from noise. This study compares NO₂hotspots detected within the city of Chicago, IL, USA using three distinct high-resolution (1.3 km) air quality products: (1) an interpolated product from Microsoft Research’s Project Eclipse—a dense network of over 100 low-cost sensors; (2) a two-way coupled WRF-CMAQ simulation; and (3) a down-sampled product using TropOMI satellite instrument observations. We use the Getis-OrdG_i^*statistic to identify hotspots of NO₂and stratify results into high-, medium-, and low-agreement hotspots, including one consensus hotspot detected in all three datasets. Interrogating medium- and low-agreement hotspots offers insights into dataset discrepancies, such as sensor placement and model physics considerations, data retrieval caveats, and the potential for missing emission inventories. When treated as complements rather than substitutes, our work demonstrates that novel air quality products can enable researchers to address discrepancies in data products and can help regulators evaluate confidence in policy-relevant insights.